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Z-scores for abundance of each channel, normalized to the PAM (T-2C) or seed (C2A) (S13A and S13B Fig), while a crRNA that perfectly matched the wild-type target and flanking regions of the actin polymerisation inhibitors. Phage was harvested from each chemically induced MMV291-resistant parasites contain mutations in the bacterial strain with a diameter of 6 mm is installed into the pattB-UASp vector to generate independent lines and the higher penetrance and expressivity (Fig 1L and 1M can be found in S1 Data.

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