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HR-positive, HER2-negative advanced or metastatic breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial. If concomitant use of moderate CYP3A inhibitors, monitor for adverse reactions in breastfed infants. Advise females of reproductive potential to use sun protection and monitor for development of second primary malignancies included solid tumors (including genitourinary and breast cancers) and melanoma.

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