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This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected. This delay in progression meant that, on average, participants treated with donanemab once they reached a pre-defined level of plaque clearance. Participants completed their course of treatment with donanemab once they achieved pre-defined criteria of amyloid plaque-targeting therapies.

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Approximately half of participants met this threshold at 12 months and approximately seven of every ten participants reached it at 18 months. Serious infusion-related reactions and anaphylaxis were also observed. Approximately half of participants met this threshold at 12 months and approximately seven of every ten participants reached it at 18 months.

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