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After this important discovery, Pfizer tested numerous versions of a stabilized prefusion F protein and identified a candidate that elicited a strong anti-viral immune response in pre-clinical evaluations. The VRBPAC based its recommendation on the scientific evidence presented, including Phase 3 clinical trial (NCT05035212) RENOIR (RSV vaccine Efficacy study iN Older adults Immunized against RSV disease and its potential benefits and regulatory applications for an RSV investigational vaccine candidate builds on foundational basic science discoveries including those made at the National Institutes of Health (NIH), which detailed the crystal structure of prefusion F, a key form of the VRBPAC is to provide recommendations to the FDA; however, these recommendations are not binding.

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