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It represents a treatment option deserving of excitement and attention. A diagnosis of PRES in patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Monitor and manage patients at risk for fractures according to established treatment guidelines and consider use of bone-targeted agents. Discontinue XTANDI in patients with this type of advanced prostate cancer.

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