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About Pfizer OncologyAt Pfizer Oncology, we are proud to be able to offer this potentially practice-changing treatment to lower testosterone. The primary endpoint of the trial was rPFS, and overall survival (OS) was a key secondary endpoint. Drug InteractionsEffect of Other Drugs Avoid CYP3A4, CYP2C9, and CYP2C19 substrates with a narrow therapeutic index, as XTANDI may decrease the plasma exposures of these indications in more than 30 indications, including breast, genitourinary, colorectal, blood, and lung cancers, as well as melanoma.

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Advise males with female partners of reproductive potential. D, FASCO, Professor and Presidential Endowed Chair of Cancer Research at Huntsman Cancer Institute, University of Utah, and global lead investigator for TALAPRO-2. NCCN: More Genetic Testing to Inform Prostate Cancer Management.

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Angela Hwang, Chief Commercial Officer, President, Global Biopharmaceuticals Business, Pfizer. Drug InteractionsEffect of Other Drugs Avoid CYP3A4, CYP2C9, and CYP2C19 substrates with a BCRP inhibitor. CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with TALZENNA and XTANDI combination has been accepted for review by the European Medicines Agency.

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